upmc   PITTSBURGH CYTOGENETICS LABORATORY

 

LABORATORY SERVICES

 

FLUORESCENCE IN SITU HYBRIDIZATION on Products of Conception (poc)

FISH analysis can be performed on fresh tissue samples or paraffin embedded tissue sections. This test is useful for detecting:

FISH FOR ANEUPLOIDY (PDF TABLE FOR PROBE LIST)

AneuVysion PROBE
SYNDROMES REGIONS PROBE REGION
Sex chromosome anueploidy Trisomy 18 Xp11.1-q11.1/ Yp11.1-q11.1/ 18p11.1-q11.1 DXZ1/ DYZ3/ D18Z1
Trisomy 13/ Trisomy 21 13q14/ 21q22.1-q22.2 RB1/ D21S259, D21S341, D21S342 (21q22.13-q22.2)

 

FISH for aCGH confirmation

BAC PROBES
Whole genomic BAC library is available for aCGH confirmation.